Brain Cells that Trigger Sugar Cravings and Consumption Identified

Most people enjoy a sweet treat every now and then. But an unchecked "sweet tooth" can lead to overconsumption of sugary foods and chronic health issues like obesity and type 2 diabetes. Understanding the biological mechanisms that control sugar intake and preference for sweet taste could have important implications for managing and preventing these health problems.

The new study, led by Matthew Potthoff, PhD, associate professor of neuroscience and pharmacology in the University of Iowa Carver College of Medicine, and Matthew Gillum, PhD, at the University of Copenhagen in Denmark, focuses on actions of a hormone called fibroblast growth factor 21 (FGF21). This hormone is known to play a role in energy balance, body weight control, and insulin sensitivity.

"This is the first study that's really identified where this hormone is acting in the brain and that has provided some very cool insights to how it's regulating sugar intake," says Potthoff, who also is a member of the Fraternal Order of Eagles Diabetes Research Center at the UI and the Iowa Neuroscience Institute.

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